REM127
REM127 is a small molecule that restores calcium homeostasis by stabilizing the septin cytoskeleton, thereby preventing pathological calcium influx in models of tauopathies. It improves synaptic plasticity, reduces tau and Aβ pathology, and rescues memory function in disease models. It exhibits a potential for treating Alzheimer’s disease and frontotemporal dementia.
| Catalog Number | E5930 |
| Molecular Formula | C28H26N4O3 |
| CAS# | 1417823-67-6 |
| Inchi | InChI=1S/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/t17-,20-,26-,28/m1/s1 |
| Inchi Key | HKSZLNNOFSGOKW-FYTWVXJKSA-N |
| SMILES | CC12C(C(CC(O1)N3C4=CC=CC=C4C5=C6C(=C7C8=CC=CC=C8N2C7=C53)CNC6=O)NC)OC |
| Size | 5mg |
| Supplier Page | http://www.selleckchem.com/products/rem127.html |
| Additional Information | https://file.selleck.cn/downloads/struct/E5930-REM127-chemical-structure.png |