PF-543
PF-543 (Sphingosine Kinase 1 Inhibitor II) is a potent, selective, reversible and sphingosine-competitive SPHK1 inhibitor with an IC50 of 2 nM and a Ki of 3.6 nM. PF-543 is >100-fold selectivity for SPHK1 over SPHK2. PF-543 is an effective potent inhibitor of sphingosine 1-phosphate (S1P) formation in whole blood with an IC50 of 26.7 nM. PF-543 induces apoptosis, necrosis, and autophagy.
| Trivial name | Sphingosine Kinase 1 Inhibitor II |
| Catalog Number | E7015 |
| Molecular Formula | C13H20N2O |
| CAS# | 1415562-82-1 |
| Inchi | InChI=1S/C13H20N2O/c1-4-9-14-11(3)13(16)15-12-8-6-5-7-10(12)2/h5-8,11,14H,4,9H2,1-3H3,(H,15,16) |
| Inchi Key | MVFGUOIZUNYYSO-UHFFFAOYSA-N |
| SMILES | CCCNC(C)C(=O)NC1=CC=CC=C1C |
| Size | 5mg |
| Supplier Page | http://www.selleckchem.com/products/pf-543-e7015.html |
| Additional Information | https://file.selleck.cn/downloads/struct/e7015-pf-543-chemical-structure-tube.png |