JNK-IN-8
JNK-IN-8 (JNK Inhibitor XVI) is the first irreversible JNK inhibitor for JNK1, JNK2 and JNK3 with IC50 of 4.7 nM, 18.7 nM and 1 nM, >10-fold selectivity against MNK2, Fms and no inhibition to c-Kit, Met, PDGFRβin A375 cell line.
| Trivial name | JNK Inhibitor XVI |
| Catalog Number | S4901 |
| Molecular Formula | C29H29N7O2 |
| CAS# | 1410880-22-6 |
| Inchi | InChI=1S/C29H29N7O2/c1-20-17-24(11-12-25(20)34-29-31-15-13-26(35-29)22-8-5-14-30-19-22)33-28(38)21-7-4-9-23(18-21)32-27(37)10-6-16-36(2)3/h4-15,17-19H,16H2,1-3H3,(H,32,37)(H,33,38)(H,31,34,35)/b10-6+ |
| Inchi Key | GJFCSAPFHAXMSF-UXBLZVDNSA-N |
| SMILES | CC1=C(C=CC(=C1)NC(=O)C2=CC(=CC=C2)NC(=O)C=CCN(C)C)NC3=NC=CC(=N3)C4=CN=CC=C4 |
| Size | 5mg |
| Supplier Page | http://www.selleckchem.com/products/jnk-in-8.html |
| Additional Information | https://file.selleck.cn/downloads/struct/JNK-IN-8-chemical-structure-s4901.gif |