JNK-IN-8
JNK-IN-8 (JNK Inhibitor XVI) is the first irreversible JNK inhibitor for JNK1, JNK2 and JNK3 with IC50 of 4.7 nM, 18.7 nM and 1 nM, >10-fold selectivity against MNK2, Fms and no inhibition to c-Kit, Met, PDGFRβin A375 cell line.
| Trivial name | JNK Inhibitor XVI |
| Catalog Number | S4901 |
| Molecular Formula | C28H44N4O8 |
| CAS# | 1410880-22-6 |
| Inchi | InChI=1S/C28H44N4O8/c1-15(2)21-19(25(32-31-21)40-26-24(36)23(35)22(34)20(13-33)39-26)12-17-7-8-18(11-16(17)3)38-10-6-9-30-14-28(4,5)27(29)37/h7-8,11,15,20,22-24,26,30,33-36H,6,9-10,12-14H2,1-5H3,(H2,2 9,37)(H,31,32)/t20-,22-,23+,24-,26+/m1/s1 |
| Inchi Key | LREHMKLEOJAVMQ-TXKDOCKMSA-N |
| SMILES | CC1=C(C=CC(=C1)OCCCNCC(C)(C)C(=O)N)CC2=C(NN=C2OC3C(C(C(C(O3)CO)O)O)O)C(C)C |
| Size | 5mg |
| Supplier Page | http://www.selleckchem.com/products/jnk-in-8.html |
| Additional Information | https://file.selleck.cn/downloads/struct/JNK-IN-8-chemical-structure-s4901.gif |