Tazemetostat (EPZ-6438)

Tazemetostat (EPZ-6438, E7438) is a potent, and selective EZH2 inhibitor with Ki and IC50 of 2.5 nM and 11 nM in cell-free assays, exhibiting a 35-fold selectivity versus EZH1 and >4,500-fold selectivity relative to 14 other HMTs.

Price Not Available 10mM/1mL Tazemetostat (EPZ-6438) Supplier Page

Trivial name	E7438
Catalog Number	S7128
Molecular Formula	C34H44N4O4
CAS#	1403254-99-8
Inchi	InChI=1S/C34H44N4O4/c1-5-38(29-10-14-41-15-11-29)32-20-28(27-8-6-26(7-9-27)22-37-12-16-42-17-13-37)19-30(25(32)4)33(39)35-21-31-23(2)18-24(3)36-34(31)40/h6-9,18-20,29H,5,10-17,21-22H2,1-4H3,(H,35,39)( H,36,40)
Inchi Key	NSQSAUGJQHDYNO-UHFFFAOYSA-N
SMILES	CCN(C1CCOCC1)C2=CC(=CC(=C2C)C(=O)NCC3=C(C=C(NC3=O)C)C)C4=CC=C(C=C4)CN5CCOCC5
Size	10mM/1mL
Supplier Page	http://www.selleckchem.com/products/epz-6438.html
Additional Information	https://file.selleck.cn/downloads/struct/EPZ-6438-chemical-structure-s7128.gif