Tazemetostat | MedChemExpress (MCE)

Tazemetostat (EPZ-6438) is a potent, selective and orally available EZH2 inhibitor. Tazemetostat inhibits the activity of human polycomb repressive complex 2 (PRC2)-containing wild-type EZH2 with a K_i value of 2.5 nM. Tazemetostat inhibits EZH2 with IC₅₀s of 11 and 16 nM in peptide assay and nucleosome assay, respectively. Tazemetostat inhibits rat EZH2 with an IC₅₀ of 4 nM. Tazemetostat also inhibits EZH1 with an IC₅₀ of 392 nM. Tazemetostat induces apoptosis and differentiation specifically in SMARCB1-deleted MRT cells^[1].

Price Not Available 100 mg Tazemetostat | MedChemExpress (MCE) Supplier Page

Trivial name	Tazemetostat
Catalog Number	HY-13803
Alternative Name(s)	EPZ-6438; E-7438
Research Area	Cancer
CAS#	1403254-99-8
Purity	99.9%
SMILES	O=C(C1=CC(C2=CC=C(CN3CCOCC3)C=C2)=CC(N(CC)C4CCOCC4)=C1C)NCC5=C(C)C=C(C)NC5=O
Size	100 mg
Supplier Page	https://www.medchemexpress.com/EPZ-6438.html