AD80
AD80, a multikinase inhibitor, shows strong activity against human RET (c-RET), BRAF, S6K, and SRC but were much less active than either AD57 or AD58 against mTOR. The IC50 value for RET is 4 nM.
| Trivial name | N/A |
| Catalog Number | S8518 |
| Molecular Formula | C22H19F4N7O |
| CAS# | 1384071-99-1 |
| Inchi | InChI=1S/C22H19F4N7O/c1-11(2)33-20-17(19(27)28-10-29-20)18(32-33)12-3-6-14(7-4-12)30-21(34)31-16-9-13(22(24,25)26)5-8-15(16)23/h3-11H,1-2H3,(H2,27,28,29)(H2,30,31,34) |
| Inchi Key | CYORWDWRQMVGHN-UHFFFAOYSA-N |
| SMILES | CC(C)N1C2=NC=NC(=C2C(=N1)C3=CC=C(C=C3)NC(=O)NC4=C(C=CC(=C4)C(F)(F)F)F)N |
| Size | 2mg |
| Supplier Page | http://www.selleckchem.com/products/ad80.html |
| Additional Information | https://file.selleck.cn/downloads/struct/ad80-chemical-structure-s8518.gif |