Paxalisib (GDC-0084)
Paxalisib (GDC-0084, RG7666) is a brain penetrant inhibitor of PI3K and mTOR with Kiapp values of 2 nM, 46 nM, 3 nM, 10 nM and 70 nM for PI3Kα, PI3Kβ, PI3Kδ, PI3Kγ and mTOR.
| Trivial name | RG7666 |
| Catalog Number | S8163 |
| Molecular Formula | C18H22N8O2 |
| CAS# | 1382979-44-3 |
| Inchi | InChI=1S/C18H22N8O2/c1-18(2)16-22-12-14(25-3-6-27-7-4-25)23-13(11-9-20-17(19)21-10-11)24-15(12)26(16)5-8-28-18/h9-10H,3-8H2,1-2H3,(H2,19,20,21) |
| Inchi Key | LGWACEZVCMBSKW-UHFFFAOYSA-N |
| SMILES | CC1(C2=NC3=C(N2CCO1)N=C(N=C3N4CCOCC4)C5=CN=C(N=C5)N)C |
| Size | 10mM/1mL |
| Supplier Page | http://www.selleckchem.com/products/gdc-0084.html |
| Additional Information | https://file.selleck.cn/downloads/struct/gdc-0084-chemical-structure-s8163.gif |