Ceritinib dihydrochloride

Ceritinib (Zykadia, LDK378) dihydrochloride is a selective, orally bioavailable and ATP-competitive inhibitor of ALK with IC50 of 0.2 nM. Ceritinib dihydrochloride also inhibits InsR, IGF-1R and STK22D with IC50 of 7 nM, 8 nM and 23 nM, respectively. Ceritinib exhibits antitomor activity.

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Trivial name	Zykadia, LDK378 dihydrochloride
Catalog Number	S4967
Molecular Formula	C28H38Cl3N5O3S
CAS#	1380575-43-8
Inchi	#N/A
Inchi Key	#N/A
SMILES	Cl.Cl.CC(C)OC1=C(NC2=NC=C(Cl)C(=N2)NC3=CC=CC=C3[S](=O)(=O)C(C)C)C=C(C)C(=C1)C4CCNCC4
Size	5mg
Supplier Page	http://www.selleckchem.com/products/ceritinib-dihydrochloride.html
Additional Information	https://file.selleck.cn/downloads/struct/s4967-ceritinib-dihydrochloride-chemical-structure.gif