Pinometostat (EPZ5676)

Pinometostat (EPZ5676) is an S-adenosyl methionine (SAM) competitive inhibitor of protein methyltransferase DOT1L with Ki of 80 pM in a cell-free assay, demonstrating >37,000-fold selectivity against all other PMTs tested, inhibits H3K79 methylation in tumor. Phase 1.

Price Not Available 50mg Pinometostat (EPZ5676) Supplier Page

Trivial name	N/A
Catalog Number	S7062
Molecular Formula	C30H42N8O3
CAS#	1380288-87-8
Inchi	InChI=1S/C30H42N8O3/c1-16(2)37(13-22-25(39)26(40)29(41-22)38-15-34-24-27(31)32-14-33-28(24)38)19-10-17(11-19)6-9-23-35-20-8-7-18(30(3,4)5)12-21(20)36-23/h7-8,12,14-17,19,22,25-26,29,39-40H,6,9-11,13H2 ,1-5H3,(H,35,36)(H2,31,32,33)/t17-,19?,22-,25-,26-,29-/m1/s1
Inchi Key	LXFOLMYKSYSZQS-JTBNCTPPSA-N
SMILES	CC(C)N(CC1C(C(C(O1)N2C=NC3=C(N=CN=C32)N)O)O)C4CC(C4)CCC5=NC6=C(N5)C=C(C=C6)C(C)(C)C
Size	50mg
Supplier Page	http://www.selleckchem.com/products/epz-5676.html
Additional Information	https://file.selleck.cn/downloads/struct/EPZ-5676-chemical-structure-s7062.gif