PF-5274857
PF-5274857 is a potent and selective Smoothened (Smo) antagonist, inhibits Hedgehog (Hh) signaling with IC50 and Ki of 5.8 nM and 4.6 nM, respectively, and can penetrate the blood–brain barrier.
| Trivial name | N/A |
| Catalog Number | S2777 |
| Molecular Formula | C20H25ClN4O3S |
| CAS# | 1373615-35-0 |
| Inchi | InChI=1S/C20H25ClN4O3S/c1-14-10-15(2)20(23-12-14)16-11-18(22-13-17(16)21)24-5-7-25(8-6-24)19(26)4-9-29(3,27)28/h10-13H,4-9H2,1-3H3 |
| Inchi Key | BBVNTTZIOTWDSV-UHFFFAOYSA-N |
| SMILES | CC1=CC(=C(N=C1)C2=CC(=NC=C2Cl)N3CCN(CC3)C(=O)CCS(=O)(=O)C)C |
| Size | 5mg |
| Supplier Page | http://www.selleckchem.com/products/pf-5274857.html |
| Additional Information | https://file.selleck.cn/downloads/struct/PF-5274857-chemical-structure-s2777.gif |