GSK J1
GSK-J1 is a highly potent inhibitor of H3K27 histone demethylase JMJD3 (KDM6B) and UTX (KDM6A) with IC50 of 60 nM in cell-free assays for JMJD3 (KDM6B) , respectively, >10-fold selectivity over other tested demethylases, with IC50 of 0.95μM and 1.76μM towards JARID1B/C.
| Trivial name | N/A |
| Catalog Number | S7581 |
| Molecular Formula | C22H23N5O2 |
| CAS# | 1373422-53-7 |
| Inchi | InChI=1S/C22H23N5O2/c28-21(29)8-12-24-19-15-20(26-22(25-19)18-7-3-4-11-23-18)27-13-9-16-5-1-2-6-17(16)10-14-27/h1-7,11,15H,8-10,12-14H2,(H,28,29)(H,24,25,26) |
| Inchi Key | AVZCPICCWKMZDT-UHFFFAOYSA-N |
| SMILES | C1CN(CCC2=CC=CC=C21)C3=NC(=NC(=C3)NCCC(=O)O)C4=CC=CC=N4 |
| Size | 10mM/1mL |
| Supplier Page | http://www.selleckchem.com/products/gsk-j1.html |
| Additional Information | https://file.selleck.cn/downloads/struct/gsk-j1-chemical-structure-s7581.gif |