Palatinose (Isomaltulose) is a disaccharide made up of glucose and fructose. Palatinose can be isolated from honey and sugar cane, with only half as sweet as sucrose. Palatinose instead of sucrose is beneficial to reduce the development of caries in animals.In Vitro: Palatinose can be fermented specifically by the serotype a, d, g strains of Streptococcus mutans, but not by the serotype b, c, e, or f strains.In Vivo: Palatinose (feeding with concentration of 56%) did not cause overt caries in rats infected with Streptococcus mutans 6715, but feeding sucrose did. Substitution of Palatinose for sucrose resulted in less caries development in rats.