Osavampator
Osavampator (TAK-653, NBI-1065845) is a positive allosteric modulator (PAM) of AMPA receptors. It enhances glutamate-induced calcium influx in CHO cells expressing human AMPA receptors with an EC50 of 3.3 µM and potentiates AMPA receptor-mediated currents in rat primary hippocampal neurons with an EC50 of 4.4 µM.
| Trivial name | TAK-653, NBI-1065845 |
| Catalog Number | E5887 |
| Molecular Formula | C37H48N4O5 |
| CAS# | 1358751-06-0 |
| Inchi | InChI=1S/C37H48N4O5/c1-25(2)34(41-20-12-19-38-37(41)45)36(44)39-30(21-28-15-7-5-8-16-28)23-32(42)31(22-29-17-9-6-10-18-29)40-33(43)24-46-35-26(3)13-11-14-27(35)4/h5-11,13-18,25,30-32,34,42H,12,19-24H2 ,1-4H3,(H,38,45)(H,39,44)(H,40,43)/t30-,31-,32-,34-/m0/s1 |
| Inchi Key | KJHKTHWMRKYKJE-SUGCFTRWSA-N |
| SMILES | CC1=C(C(=CC=C1)C)OCC(=O)NC(CC2=CC=CC=C2)C(CC(CC3=CC=CC=C3)NC(=O)C(C(C)C)N4CCCNC4=O)O |
| Size | 5mg |
| Supplier Page | http://www.selleckchem.com/products/osavampator.html |
| Additional Information | https://file.selleck.cn/downloads/struct/E5887-Osavampator-chemical-structure.png |