Osavampator
Osavampator (TAK-653, NBI-1065845) is a positive allosteric modulator (PAM) of AMPA receptors. It enhances glutamate-induced calcium influx in CHO cells expressing human AMPA receptors with an EC50 of 3.3 µM and potentiates AMPA receptor-mediated currents in rat primary hippocampal neurons with an EC50 of 4.4 µM.
| Trivial name | TAK-653, NBI-1065845 |
| Catalog Number | E5887 |
| Molecular Formula | C17H25N3O5S |
| CAS# | 1358751-06-0 |
| Inchi | InChI=1S/C17H25N3O5S/c1-7-12-11(8(2)21)16(23)20(12)13(17(24)25)14(7)26-9-5-10(18-6-9)15(22)19(3)4/h7-12,18,21H,5-6H2,1-4H3,(H,24,25) |
| Inchi Key | DMJNNHOOLUXYBV-UHFFFAOYSA-N |
| SMILES | CC1C2C(C(=O)N2C(=C1SC3CC(NC3)C(=O)N(C)C)C(=O)O)C(C)O |
| Size | 25mg |
| Supplier Page | http://www.selleckchem.com/products/osavampator.html |
| Additional Information | https://file.selleck.cn/downloads/struct/E5887-Osavampator-chemical-structure.png |