Osavampator
Osavampator (TAK-653, NBI-1065845) is a positive allosteric modulator (PAM) of AMPA receptors. It enhances glutamate-induced calcium influx in CHO cells expressing human AMPA receptors with an EC50 of 3.3 µM and potentiates AMPA receptor-mediated currents in rat primary hippocampal neurons with an EC50 of 4.4 µM.
| Trivial name | TAK-653, NBI-1065845 |
| Catalog Number | E5887 |
| Molecular Formula | C18H20N2·HCl |
| CAS# | 1358751-06-0 |
| Inchi | InChI=1S/C18H20N2.ClH/c1-19-10-11-20-17-9-5-3-7-15(17)12-14-6-2-4-8-16(14)18(20)13-19;/h2-9,18H,10-13H2,1H3;1H |
| Inchi Key | YNPFMWCWRVTGKJ-UHFFFAOYSA-N |
| SMILES | CN1CCN2C(C1)C3=CC=CC=C3CC4=CC=CC=C42.Cl |
| Size | 100mg |
| Supplier Page | http://www.selleckchem.com/products/osavampator.html |
| Additional Information | https://file.selleck.cn/downloads/struct/E5887-Osavampator-chemical-structure.png |