C25-140
C25-140 is a small-molecule inhibitor of TRAF6-Ubc13 interaction. C25-140 directly binds to TRAF6, thereby blocking the interaction of TRAF6 with Ubc13, and as a consequence lowers TRAF6 activity. C25-140 impedes NF-κB activation in various immune and inflammatory signaling pathways also in primary human and murine cells.
| Trivial name | N/A |
| Catalog Number | S6679 |
| Molecular Formula | C26H31N7O |
| CAS# | 1358099-18-9 |
| Inchi | InChI=1S/C26H31N7O/c1-18-23(19(2)32(29-18)25-11-10-24-28-27-20(3)33(24)30-25)9-12-26(34)31-15-13-22(14-16-31)17-21-7-5-4-6-8-21/h4-8,10-11,22H,9,12-17H2,1-3H3 |
| Inchi Key | HFKVRXVHZGBRKF-UHFFFAOYSA-N |
| SMILES | CC1=C(C(=NN1C2=NN3C(=NN=C3C=C2)C)C)CCC(=O)N4CCC(CC4)CC5=CC=CC=C5 |
| Size | 10mM/1mL |
| Supplier Page | http://www.selleckchem.com/products/c25-140.html |
| Additional Information | https://file.selleck.cn/downloads/struct/c25-140-chemical-structure-s6679.gif |