Theliatinib (HMPL-309)

Theliatinib (HMPL-309) is a highly potent EGFR inhibitor with Ki value of 0.05 nM against the wild type EGFR and IC50 values of 3 nM and 22 nM against EGFR and EGFR T790M/L858R mutant. It demonstrats 50 fold greater selectivity for EGFR compared to 72 other kinases.

Price Not Available 5mg Theliatinib (HMPL-309) Supplier Page

Trivial name	N/A
Catalog Number	S8584
Molecular Formula	C25H26N6O2
CAS#	1353644-70-8
Inchi	InChI=1S/C25H26N6O2/c1-4-16-6-5-7-18(10-16)28-24-19-11-21(23(33-3)12-20(19)26-15-27-24)29-25(32)31-13-17-8-9-30(2)22(17)14-31/h1,5-7,10-12,15,17,22H,8-9,13-14H2,2-3H3,(H,29,32)(H,26,27,28)/t17-,22+/m1 /s1
Inchi Key	FSXCKIBROURMFT-VGSWGCGISA-N
SMILES	COC1=C(NC(=O)N2CC3CCN(C)C3C2)C=C4C(=NC=NC4=C1)NC5=CC(=CC=C5)C#C
Size	5mg
Supplier Page	http://www.selleckchem.com/products/theliatinib-hmpl-309.html
Additional Information	https://file.selleck.cn/downloads/struct/theliatinib-hmpl-309-chemical-structure-s8584.gif