Thiol-PEG6-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.In Vitro:PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.