GSK583
GSK583 is a highly potent and selective inhibitor of RIP2 kinase with IC50 of 5 nM. GSK583 also inhibits both TNF-α and IL-6 production with IC50 of ~200 nM in explant cultures.
| Trivial name | N/A |
| Catalog Number | S8261 |
| Molecular Formula | C20H19FN4O2S |
| CAS# | 1346547-00-9 |
| Inchi | InChI=1S/C20H19FN4O2S/c1-20(2,3)28(26,27)13-5-7-16-14(11-13)17(8-9-22-16)23-19-15-10-12(21)4-6-18(15)24-25-19/h4-11H,1-3H3,(H2,22,23,24,25) |
| Inchi Key | XLOGLWKOHPIJLV-UHFFFAOYSA-N |
| SMILES | CC(C)(C)S(=O)(=O)C1=CC2=C(C=CN=C2C=C1)NC3=NNC4=C3C=C(C=C4)F |
| Size | 2mg |
| Supplier Page | http://www.selleckchem.com/products/gsk583.html |
| Additional Information | https://file.selleck.cn/downloads/struct/gsk583-chemical-structure-s8261.gif |