ETP-46464

A potent ATR (ATM and Rad3-related) inhibitor (IC50 = 25 nM). It also inhibits the activity of PI3Kα, mTOR and DNA-PKC with IC50’s of 170, 0.6 and 36 nM, respectively. ETP-46464 inhibits the restart of stalled replication forks and abrogates S phase arrest after exposure to hydroxyurea.

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Catalog Number	ABM-005
Alternative Name(s)	2-Methyl-2-(4-(2-oxo-9-(quinolin-3-yl)-2H-[1,3]oxazino[5,4-c]quinolin-1(4H)-yl)phenyl)propanenitrile; ATRi
CAS#	1345675-02-6
Inchi	InChI=1S/C30H22N4O2/c1-30(2,18-31)23-8-10-24(11-9-23)34-28-22(17-36-29(34)35)16-33-27-12-7-19(14-25(27)28)21-13-20-5-3-4-6-26(20)32-15-21/h3-16H,17H2,1-2H3
Inchi Key	DPLMXAYKJZOTKO-UHFFFAOYSA-N
SMILES	CC(C)(C#N)C(C=C1)=CC=C1N(C2=C(CO3)C=NC(C2=C4)=CC=C4C5=CC6=CC=CC=C6N=C5)C3=O
Size	Inquiry
Supplier Page	https://www.agingclocks.com/etp-46464-item-1450.html