GSK2656157
GSK2656157 is an ATP-competitive and highly selective inhibitor of PERK with IC50 of 0.9 nM in a cell-free assay, 500-fold greater against a panel of 300 kinases. GSK2656157 decreases apoptosis and inhibits excessive autophagy.
| Trivial name | N/A |
| Catalog Number | S7033 |
| Molecular Formula | C23H21FN6O |
| CAS# | 1337532-29-2 |
| Inchi | InChI=1S/C23H21FN6O/c1-13-4-3-5-14(28-13)10-19(31)30-9-8-16-18(30)7-6-15(21(16)24)17-11-29(2)23-20(17)22(25)26-12-27-23/h3-7,11-12H,8-10H2,1-2H3,(H2,25,26,27) |
| Inchi Key | PRWSIEBRGXYXAJ-UHFFFAOYSA-N |
| SMILES | CC1=NC(=CC=C1)CC(=O)N2CCC3=C2C=CC(=C3F)C4=CN(C5=NC=NC(=C45)N)C |
| Size | 5mg |
| Supplier Page | http://www.selleckchem.com/products/gsk2656157.html |
| Additional Information | https://file.selleck.cn/downloads/struct/GSK2656157-chemical-structure-s7033.gif |