AG-490
AG-490 is an inhibitor of EGFR with IC50 of 0.1 μM in cell-free assays, 135-fold more selective for EGFR versus ErbB2, also inhibits JAK2 with no activity to Lck, Lyn, Btk, Syk and Src.
| Trivial name | Tyrphostin B42, Zinc02557947 |
| Catalog Number | S1143 |
| Molecular Formula | C17H14N2O3 |
| CAS# | 133550-30-8 |
| Inchi | InChI=1S/C17H14N2O3/c18-10-14(8-13-6-7-15(20)16(21)9-13)17(22)19-11-12-4-2-1-3-5-12/h1-9,20-21H,11H2,(H,19,22)/b14-8+ |
| Inchi Key | TUCIOBMMDDOEMM-RIYZIHGNSA-N |
| SMILES | C1=CC=C(C=C1)CNC(=O)C(=CC2=CC(=C(C=C2)O)O)C#N |
| Size | 10mg |
| Supplier Page | http://www.selleckchem.com/products/AG-490.html |
| Additional Information | https://file.selleck.cn/downloads/struct/AG-490-chemical-structure-S1143.gif |