PF-5190457 (PF-05190457) is a potent and selective ghrelin receptor inverse agonist with a pKi of 8.36.IC50 & Target: pKi: 8.36 (Humnan ghrelin receptor)In Vitro: PF-5190457 has a superior balance of ghrelin receptor pharmacology and off-target selectivity.In Vivo: PF-5190457 has excellent selectivity and demonstrates robust increases in glucose-stimulated insulin secretion in human whole and dispersed islets.