PF-04995274

PF-04995274 (PF-4995274) is a potent, high-affinity, orally active and partial agonist of serotonin 4 receptor (5-HT4R) with EC50 of 0.47 nM, 0.36 nM, 0.37 nM and 0.26 nM for human 5-HT4A/4B/4D/4E, respectively. As for rat 5-HT4S/4L/4E, the EC50 is 0.59 nM, 0.65 nM and 0.62 nM, respectively. PF-04995274 is brain penetrant and can be used for cognitive disorders associated with Alzheimer’s disease.

Price Not Available 5mg PF-04995274 Supplier Page
Trivial name PF-4995274
Catalog Number S0496
Molecular Formula C23H32N2O6
CAS# 1331782-27-4
SMILES C1CN(CCC1COC2=NOC3=C2C(=CC=C3)OC4CCOC4)CC5(CCOCC5)O
Size 5mg
Supplier Page http://www.selleckchem.com/products/pf-04995274.html
Additional Information https://file.selleck.cn/downloads/struct/s0496-pf-04995274-chemical-structure.gif