Bisindolylmaleimide I (GF109203X)
Bisindolylmaleimide I (GF109203X, GO 6850) is a potent PKC inhibitor with IC50 of 20 nM, 17 nM, 16 nM, and 20 nM for PKCα, PKCβI, PKCβII, and PKCγ in cell-free assays, respectively, showing more than 3000-fold selectivity for PKC as compared to EGFR, PDGFR and insulin receptor.
| Trivial name | GO 6850 |
| Catalog Number | S7208 |
| Molecular Formula | C25H24N4O2 |
| CAS# | 133052-90-1 |
| Inchi | InChI=1S/C25H24N4O2/c1-28(2)12-7-13-29-15-19(17-9-4-6-11-21(17)29)23-22(24(30)27-25(23)31)18-14-26-20-10-5-3-8-16(18)20/h3-6,8-11,14-15,26H,7,12-13H2,1-2H3,(H,27,30,31) |
| Inchi Key | QMGUOJYZJKLOLH-UHFFFAOYSA-N |
| SMILES | CN(C)CCCN1C=C(C2=CC=CC=C21)C3=C(C(=O)NC3=O)C4=CNC5=CC=CC=C54 |
| Size | 10mg |
| Supplier Page | http://www.selleckchem.com/products/gf109203x.html |
| Additional Information | https://file.selleck.cn/downloads/struct/GF-109203X-Go-6850-chemical-structure-s7208.gif |