STL127705
STL127705 is a potent small molecule inhibitor of Ku70/80 heterodimer protein with an IC50 of 3.5 μM. It disrupts Non-Homologous End-Joining (NHEJ) by preventing DNA binding and inhibiting DNA-PKCS activation. It exhibits anticancer activity by inducing apoptosis and inhibiting cell proliferation.
| Catalog Number | E4784 |
| Molecular Formula | C20H19N3O.CH4O3S |
| CAS# | 1326852-06-5 |
| Inchi | InChI=1S/C20H19N3O.CH4O3S/c1-12-8-13(2)21-16(12)10-19-20(24-3)11-18(23-19)17-9-14-6-4-5-7-15(14)22-17;1-5(2,3)4/h4-11,21-22H,1-3H3;1H3,(H,2,3,4)/b19-10-; |
| Inchi Key | ZFKXDVMHNXPEIY-PEZBNFGJSA-N |
| SMILES | CC1=CC(=C(N1)C=C2C(=CC(=C3C=C4C=CC=CC4=N3)N2)OC)C.CS(=O)(=O)O |
| Size | 25mg |
| Supplier Page | http://www.selleckchem.com/products/stl127705.html |
| Additional Information | https://file.selleck.cn/downloads/struct/E4784-STL127705-chemical-structure.png |