STL127705
STL127705 is a potent small molecule inhibitor of Ku70/80 heterodimer protein with an IC50 of 3.5 μM. It disrupts Non-Homologous End-Joining (NHEJ) by preventing DNA binding and inhibiting DNA-PKCS activation. It exhibits anticancer activity by inducing apoptosis and inhibiting cell proliferation.
| Catalog Number | E4784 |
| Molecular Formula | C22H20N4O |
| CAS# | 1326852-06-5 |
| Inchi | InChI=1S/C22H20N4O/c1-25(2)22(27)15-26-14-19(12-24-26)16-7-9-17(10-8-16)21-13-23-11-18-5-3-4-6-20(18)21/h3-14H,15H2,1-2H3 |
| Inchi Key | WULUGQONDYDNKY-UHFFFAOYSA-N |
| SMILES | CN(C)C(=O)CN1C=C(C=N1)C2=CC=C(C=C2)C3=CN=CC4=CC=CC=C43 |
| Size | 1g |
| Supplier Page | http://www.selleckchem.com/products/stl127705.html |
| Additional Information | https://file.selleck.cn/downloads/struct/E4784-STL127705-chemical-structure.png |