Flavopiridol (Alvocidib) HCl

Flavopiridol (Alvocidib) HCl competes with ATP to inhibit CDKs including CDK1, CDK2, CDK4 and CDK6 with IC50 of ~ 40 nM in cell-free assays. It is 7.5-fold more selective for CDK1/2/4/6 than CDK7. Flavopiridol is initially found to inhibit EGFR and PKA. Flavopiridol HCl induces autophagy and ER stress. Flavopiridol HCl blocks HIV-1 replication. Phase 1/2.

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Trivial name	NSC 649890, L86-8275, HMR-1275, DSP-2033
Catalog Number	S2679
Molecular Formula	C21H20ClNO5.HCl
CAS#	131740-09-5
Inchi	InChI=1S/C21H20ClNO5.ClH/c1-23-7-6-12(17(27)10-23)19-14(24)8-15(25)20-16(26)9-18(28-21(19)20)11-4-2-3-5-13(11)22;/h2-5,8-9,12,17,24-25,27H,6-7,10H2,1H3;1H/t12-,17+;/m0./s1
Inchi Key	LGMSNQNWOCSPIK-LWHGMNCYSA-N
SMILES	CN1CCC(C(C1)O)C2=C(C=C(C3=C2OC(=CC3=O)C4=CC=CC=C4Cl)O)O.Cl
Size	10mg
Supplier Page	http://www.selleckchem.com/products/flavopiridol-hydrochloride.html
Additional Information	https://file.selleck.cn/downloads/struct/Flavopiridol-hydrochloride-chemical-structure-S2679.gif