Ricolinostat (ACY-1215)
Ricolinostat (ACY-1215, Rocilinostat) is a selective HDAC6 inhibitor with IC50 of 5 nM in a cell-free assay. It is >10-fold more selective for HDAC6 than HDAC1/2/3 (class I HDACs) with slight activity against HDAC8, minimal activity against HDAC4/5/7/9/11, Sirtuin1, and Sirtuin2. Ricolinostat (ACY-1215) suppresses cell proliferation and promotes apoptosis. Phase 2.
| Trivial name | Rocilinostat |
| Catalog Number | S8001 |
| Molecular Formula | C24H27N5O3 |
| CAS# | 1316214-52-4 |
| Inchi | InChI=1S/C24H27N5O3/c30-22(28-32)15-9-1-2-10-16-25-23(31)19-17-26-24(27-18-19)29(20-11-5-3-6-12-20)21-13-7-4-8-14-21/h3-8,11-14,17-18,32H,1-2,9-10,15-16H2,(H,25,31)(H,28,30) |
| Inchi Key | QGZYDVAGYRLSKP-UHFFFAOYSA-N |
| SMILES | C1=CC=C(C=C1)N(C2=CC=CC=C2)C3=NC=C(C=N3)C(=O)NCCCCCCC(=O)NO |
| Size | 1g |
| Supplier Page | http://www.selleckchem.com/products/rocilinostat-acy-1215.html |
| Additional Information | https://file.selleck.cn/downloads/struct/Rocilinostat-ACY-1215-chemical-structure-s8001.jpg |