Pyr10
Pyr10 is a pyrazole derivative and a selective TRP cation 3 (TRPC3) inhibitor. Pyr10 inhibits Ca2+ influx in carbachol-stimulated TRPC3-transfected HEK293 cells with an IC50 of 0.72 μM (IC50 of 13.08 μM for store operated Ca2+ entry in BRL-2H3 cells). Pyr10 has the ability to distinguish between receptor-operated TRPC3 and native stromal interaction molecule 1 (STIM1)/Orai1 channels.
| Catalog Number | E7635 |
| Molecular Formula | C15H13NO3S2 |
| CAS# | 1315323-00-2 |
| Inchi | InChI=1S/C15H13NO3S2/c1-10(7-11-5-3-2-4-6-11)8-12-14(19)16(9-13(17)18)15(20)21-12/h2-8H,9H2,1H3,(H,17,18)/b10-7+,12-8- |
| Inchi Key | CHNUOJQWGUIOLD-NFZZJPOKSA-N |
| SMILES | CC(=CC1=CC=CC=C1)C=C2C(=O)N(C(=S)S2)CC(=O)O |
| Size | 5mg |
| Supplier Page | http://www.selleckchem.com/products/pyr10.html |
| Additional Information | https://file.selleck.cn/downloads/struct/e7635-pyr10-chemical-structure-tube.png |