Nirogacestat (PF-03084014)

Nirogacestat (PF-03084014, PF-3084014) is a selective gamma-secretase inhibitor with IC50 of 6.2 nM in a cell-free assay. Nirogacestat (PF-03084014, PF-3084014) induces apoptosis. Phase 2.

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Trivial name	PF-3084014
Catalog Number	S8018
Molecular Formula	C27H41F2N5O
CAS#	1290543-63-3
Inchi	InChI=1S/C27H41F2N5O/c1-7-8-23(32-20-10-9-18-11-19(28)12-22(29)21(18)13-20)25(35)33-24-14-34(17-31-24)27(5,6)16-30-15-26(2,3)4/h11-12,14,17,20,23,30,32H,7-10,13,15-16H2,1-6H3,(H,33,35)/t20-,23-/m0/s1
Inchi Key	VFCRKLWBYMDAED-REWPJTCUSA-N
SMILES	CCCC(C(=O)NC1=CN(C=N1)C(C)(C)CNCC(C)(C)C)NC2CCC3=C(C2)C(=CC(=C3)F)F
Size	1g
Supplier Page	http://www.selleckchem.com/products/pf-03084014-pf-3084014.html
Additional Information	https://file.selleck.cn/downloads/struct/pf-03084014-chemical-structure-s8018.gif