Varoglutamstat
Varoglutamstat (PQ912) is an inhibitor of glutaminyl cyclase (QC), inhibiting human glutaminyl cyclase (hQC) activity with a Ki of 25 nM (pH 8.0). It reduces pyroglutamyl-Aβ (pE-Aβ) levels and can be used in Alzheimer’s disease research.
| Trivial name | PQ912 |
| Catalog Number | S0792 |
| Molecular Formula | C26H27N5O2 |
| CAS# | 1276021-65-8 |
| Inchi | InChI=1S/C26H27N5O2/c27-16-18-4-6-23-22(13-18)19(17-29-23)3-1-2-8-30-9-11-31(12-10-30)21-5-7-24-20(14-21)15-25(33-24)26(28)32/h4-7,13-15,17,29H,1-3,8-12H2,(H2,28,32) |
| Inchi Key | SGEGOXDYSFKCPT-UHFFFAOYSA-N |
| SMILES | C1CN(CCN1CCCCC2=CNC3=C2C=C(C=C3)C#N)C4=CC5=C(C=C4)OC(=C5)C(=O)N |
| Size | 25mg |
| Supplier Page | http://www.selleckchem.com/products/pq912.html |
| Additional Information | https://file.selleck.cn/downloads/struct/S0792-Varoglutamstat-chemical-structure.png |