Isuzinaxib (APX-115 free base)
Isuzinaxib (APX-115 free base, Ewha-18278 free base) is a potent, orally active inhibitor of pan NADPH oxidase (pan-Nox) with Ki of 1.08 μM, 0.57 μM, and 0.63 μM for Nox1, Nox2 and Nox4, respectively. APX-115 free base (Ewha-18278 free base) significantly suppresses the expression of inflammatory molecules including MCP-1/CCL2, IL-6, and TNFα in the diabetic kidney.
| Trivial name | Ewha-18278 free base |
| Catalog Number | S0777 |
| Molecular Formula | C17H17N3O |
| CAS# | 1270084-92-8 |
| SMILES | CCCC1=C(NN(C1=O)C2=CC=CC=N2)C3=CC=CC=C3 |
| Size | 10mM/1mL |
| Supplier Page | http://www.selleckchem.com/products/apx-115-free-base.html |
| Additional Information | https://file.selleck.cn/downloads/struct/s0777-apx-115-free-base-chemical-structure.gif |