(+)-JQ1
(+)-JQ1 is a BET bromodomain inhibitor, with IC50 of 77 nM/33 nM for BRD4(1/2) in cell-free assays, binding to all bromodomains of the BET family, but not to bromodomains outside the BET family. (+)-JQ1 suppresses cell proliferation via inducing autophagy. (+)-JQ1 inhibits the expression of Nuclear receptor binding SET domain protein 3 (NSD3) target genes.
| Trivial name | N/A |
| Catalog Number | S7110 |
| Molecular Formula | C23H25ClN4O2S |
| CAS# | 1268524-70-4 |
| Inchi | InChI=1S/C23H25ClN4O2S/c1-12-13(2)31-22-19(12)20(15-7-9-16(24)10-8-15)25-17(11-18(29)30-23(4,5)6)21-27-26-14(3)28(21)22/h7-10,17H,11H2,1-6H3/t17-/m0/s1 |
| Inchi Key | DNVXATUJJDPFDM-KRWDZBQOSA-N |
| SMILES | CC1=C(SC2=C1C(=NC(C3=NN=C(N32)C)CC(=O)OC(C)(C)C)C4=CC=C(C=C4)Cl)C |
| Size | 10mM/1mL |
| Supplier Page | http://www.selleckchem.com/products/jq1.html |
| Additional Information | https://file.selleck.cn/downloads/struct/JQ1-chemical-structure-s7110.gif |