PF-4708671
PF-4708671 is a cell-permeable inhibitor of p70 ribosomal S6 kinase (S6K1 isoform) with Ki/IC50 of 20 nM/160 nM in cell-free assays, 400-fold greater selectivity for S6K1 than S6K2, and 4- and >20-fold selectivity for S6K1 than MSK1 and RSK1/2, respectively. PF-4708671 induces autophagy. First S6K1-specific inhibitor to be reported.
| Trivial name | N/A |
| Catalog Number | S2163 |
| Molecular Formula | C30H41FN4O12 |
| CAS# | 1255517-76-0 |
| Inchi | InChI=1S/C31H42FN3O12/c1-18(2)28(30(42)33-22(24(37)16-32)15-27(40)46-5)35-29(41)20(11-12-25(38)44-3)13-23(36)21(14-26(39)45-4)34-31(43)47-17-19-9-7-6-8-10-19/h6-10,18,20-22,28H,11-17H2,1-5H3,(H,33,42) (H,34,43)(H,35,41)/t20-,21-,22-,28-/m0/s1 |
| Inchi Key | RXCJOCFDARLNSM-STFWXSJUSA-N |
| SMILES | CC(C)C(C(=O)NC(CC(=O)OC)C(=O)CF)NC(=O)C(CCC(=O)OC)NC(=O)C(CC(=O)OC)NC(=O)OCC1=CC=CC=C1 |
| Size | 10mg |
| Supplier Page | http://www.selleckchem.com/products/pf-4708671.html |
| Additional Information | https://file.selleck.cn/downloads/struct/PF-4708671-chemical-structure-s2163.gif |