Saclofen
Saclofen is an orally available competitive GABAB receptor antagonist with an IC50 of 7.8 μM, but it has a weaker antagonistic effect on GABAB1b and GABAB2 heterodimer recombinant receptors. Saclofen can inhibit the binding of baclofen (HY-B007) to rat cerebellar membranes and block the phase shifts in circadian rhythms caused by baclofen. Saclofen has also shown anti-inflammatory and analgesic effects in rats.
| Catalog Number | E7208 |
| Molecular Formula | C21H28O2 |
| CAS# | 125464-42-8 |
| Inchi | InChI=1S/C21H28O2/c1-3-20-11-9-17-16-8-6-15(22)13-14(16)5-7-18(17)19(20)10-12-21(20,23)4-2/h2,13,16-19,23H,3,5-12H2,1H3/t16-,17+,18+,19-,20-,21-/m0/s1 |
| Inchi Key | WWYNJERNGUHSAO-XUDSTZEESA-N |
| SMILES | CCC12CCC3C(C1CCC2(C#C)O)CCC4=CC(=O)CCC34 |
| Size | 5mg |
| Supplier Page | http://www.selleckchem.com/products/saclofen.html |
| Additional Information | https://file.selleck.cn/downloads/struct/e7208-saclofen-chemical-structure-tube.png |