LY2874455
LY2874455 is a pan-FGFR inhibitor with IC50 of 2.8 nM, 2.6 nM, 6.4 nM, and 6 nM for FGFR1, FGFR2, FGFR3, and FGFR4, respectively, and also inhibits VEGFR2 activity with IC50 of 7 nM. Phase 1.
| Trivial name | N/A |
| Catalog Number | S7057 |
| Molecular Formula | C21H19Cl2N5O2 |
| CAS# | 1254473-64-7 |
| Inchi | InChI=1S/C21H19Cl2N5O2/c1-13(21-17(22)10-24-11-18(21)23)30-15-3-5-20-16(8-15)19(26-27-20)4-2-14-9-25-28(12-14)6-7-29/h2-5,8-13,29H,6-7H2,1H3,(H,26,27)/b4-2+/t13-/m1/s1 |
| Inchi Key | GKJCVYLDJWTWQU-CXLRFSCWSA-N |
| SMILES | CC(C1=C(C=NC=C1Cl)Cl)OC2=CC3=C(C=C2)NN=C3C=CC4=CN(N=C4)CCO |
| Size | 5mg |
| Supplier Page | http://www.selleckchem.com/products/ly2874455.html |
| Additional Information | https://file.selleck.cn/downloads/struct/ly2874455-chemical-structure-s7057.gif |