Ro 31-8220
Ro 31-8220 is a potent PKC inhibitor, with IC50s of 5, 24, 14, 27, 24 and 23 nM for PKCα, PKCβI, PKCβII, PKCγ, PKCε and rat brain PKC, respectively. Ro 31-8220 also significantly inhibits MAPKAP-K1b, MSK1, S6K1 and GSK3β (IC50s, 3, 8, 15, and 38 nM, respectively), with no effect on MKK3, MKK4, MKK6 and MKK7.
| Trivial name | Bisindolylmaleimide IX |
| Catalog Number | E8188 |
| Molecular Formula | C23H22O6 |
| CAS# | 125314-64-9 |
| Inchi | InChI=1S/C23H22O6/c1-11(2)16-8-14-15(28-16)6-5-12-22(24)21-13-7-18(25-3)19(26-4)9-17(13)27-10-20(21)29-23(12)14/h5-7,9,16,20-21H,1,8,10H2,2-4H3/t16?,20-,21+/m1/s1 |
| Inchi Key | JUVIOZPCNVVQFO-XHEPWMPHSA-N |
| Size | 5mg |
| Supplier Page | http://www.selleckchem.com/products/ro-31-8220.html |
| Additional Information | https://file.selleck.cn/downloads/struct/e8188-ro-31-8220-chemical-structure-tube.png |