7-oxo Staurosporine
7-oxo Staurosporine is an antibiotic originally isolated from S. platensis with diverse biological activites. It inhibits PKC, PKA, phosphorylase kinase, EGFR, and c-Src in vitro (IC50s = 9, 26, 5, 200, and 800 nM, respectively). 7-oxo Staurosporine induces cell cycle arrest in the G2/M phase in human leukemia K562 cells with a minimal effective dose (MED) of 30 ng/ml. It is cytotoxic to P388 mouse leukemia cells that are resistant and susceptible to doxorubicin . 7-oxo Staurosporine inhibits growth of the mycelial, but not yeast form of C. albicans, C. krusei, C. tropicalis, and C. lusitaniae (MICs = 3.1-25 μg/ml). It increases sphingomyelin synthesis in CHO-K1 cells when used at a concentration of 50 nM.
Catalog Number | T35423 |
Molecular Formula | C28H24N4O4 |
CAS# | 125035-83-8 |
SMILES | C[C@]12N3C=4C5=C(C6=C(C4C=7C3=CC=CC7)C(=O)NC6=O)C=8C(N5[C@](O1)(C[C@@H](NC)[C@H]2OC)[H])=CC=CC8 |
Size | 5 mg |
Supplier Page | https://www.targetmol.com/compound/7-oxo_staurosporine |
Additional Information | https://www.targetmol.com/datasheet/T35423 |