Topotecan Hydrochloride

Topotecan Hydrochloride is the water-soluble hydrochloride salt preparation of Topotecan, a potent inhibitor of topoisomerase 1, and an apoptosis inducer, producing proapoptotic and antiproliferative effects. Topotecan is a semisynthetic derivative of the natural product alkaloid camptothecin. It is described to stabilize topoisomerase I/DNA cleavable complexes and promote rapid apoptotic cell death in radiation-resistant human B-lineage acute lymphoblastic leukemia cells.

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Catalog Number	10-101-124
Alternative Name(s)	TPT, SKF-104864A, SKFS-104864-A, 9-[(Dimethylamino)methyl]-10-hydroxy-(20S)-camptothecin · HCl, (S)-10-Dimethylaminomethyl-4-ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2b]quinoline-3,14(4H,12H)-dione · HCl, (20S)-10-Dimethylaminomethyl-4-ethyl
Research Area	Ovarian cancer & Cervical cancer & Small cell lung cancer (SCLC)
Molecular Formula	C23H23N3O5
CAS#	119413-54-6
Purity	>95%
Inchi	InChI=1S/C23H23N3O5/c1-4-23(30)16-8-18-20-12(9-26(18)21(28)15(16)11-31-22(23)29)7-13-14(10-25(2)3)19(27)6-5-17(13)24-20/h5-8,27,30H,4,9-11H2,1-3H3/t23-/m0/s1
Inchi Key	UCFGDBYHRUNTLO-QHCPKHFHSA-N
SMILES	CC[C@@]1(C2=C(COC1=O)C(=O)N3CC4=C(C3=C2)N=C5C=CC(=C(C5=C4)CN(C)C)O)O
Size	Inquiry
Supplier Page	https://www.creative-peptides.com/product/topotecan-hydrochloride-item-10-101-124-112.html