Marinopyrrole A (Maritoclax)
Marinopyrrole A (Maritoclax) is a selective Mcl-1 antagonist. It binds to Mcl-1, but not Bcl-XL, and targets Mcl-1 for proteasomal degradation. Maritoclax disrupts the interaction between Bim and Mcl-1 with an IC50 of 10.1 μM.
Trivial name | N/A |
Catalog Number | S7126 |
Molecular Formula | C22H12Cl4N2O4 |
CAS# | 1227962-62-0 |
Inchi | InChI=1S/C22H12Cl4N2O4/c23-12-9-13(19(31)10-5-1-3-7-14(10)29)28(22(12)26)18-16(24)21(25)27-17(18)20(32)11-6-2-4-8-15(11)30/h1-9,27,29-30H |
Inchi Key | QYPJBTMRYKRTFG-UHFFFAOYSA-N |
SMILES | C1=CC=C(C(=C1)C(=O)C2=CC(=C(N2C3=C(NC(=C3Cl)Cl)C(=O)C4=CC=CC=C4O)Cl)Cl)O |
Size | 5mg |
Supplier Page | http://www.selleckchem.com/products/marinopyrrole-a-maritoclax.html |
Additional Information | https://file.selleck.cn/downloads/struct/marinopyrrole-a-chemical-structure-s7126.gif |