BAY 87-2243
BAY 87-2243 is a potent and selective hypoxia-inducible factor-1 (HIF-1) inhibitor. BAY 87-2243 inhibits mitochondrial complex I activity, thus triggering a mitophagy-dependent ROS increase leading to necroptosis and ferroptosis. BAY 87-2243 exerts antitumor activity. Phase 1.
| Trivial name | N/A |
| Catalog Number | S7309 |
| Molecular Formula | C26H26F3N7O2 |
| CAS# | 1227158-85-1 |
| Inchi | InChI=1S/C26H26F3N7O2/c1-17-14-22(25-31-24(33-38-25)19-2-6-21(7-3-19)37-26(27,28)29)32-36(17)16-18-8-9-30-23(15-18)35-12-10-34(11-13-35)20-4-5-20/h2-3,6-9,14-15,20H,4-5,10-13,16H2,1H3 |
| Inchi Key | CDJNNOJINJAXPV-UHFFFAOYSA-N |
| SMILES | CC1=CC(=NN1CC2=CC(=NC=C2)N3CCN(CC3)C4CC4)C5=NC(=NO5)C6=CC=C(C=C6)OC(F)(F)F |
| Size | 1g |
| Supplier Page | http://www.selleckchem.com/products/bay-87-2243.html |
| Additional Information | https://file.selleck.cn/downloads/struct/BAY-87-2243-chemical-structure-s7309.gif |