Rigosertib (ON-01910)

Rigosertib (ON-01910) is a non-ATP-competitive inhibitor of PLK1 with IC50 of 9 nM in a cell-free assay. It shows 30-fold greater selectivity against Plk2 and no activity to Plk3. Rigosertib inhibits PI3K/Akt pathway and activates oxidative stress signals. Rigosertib induces apoptosis in various cancer cells. Phase 3.

Price Not Available 5mg Rigosertib (ON-01910) Supplier Page
Trivial name N/A
Catalog Number S1362
Molecular Formula C21H24NNaO8S
CAS# 1225497-78-8
Inchi InChI=1S/C21H25NO8S.Na/c1-27-15-10-19(29-3)16(20(11-15)30-4)7-8-31(25,26)13-14-5-6-18(28-2)17(9-14)22-12-21(23)24;/h5-11,22H,12-13H2,1-4H3,(H,23,24);/q;+1/p-1/b8-7+;
Inchi Key VLQLUZFVFXYXQE-USRGLUTNSA-M
SMILES COC1=C(C=C(C=C1)CS(=O)(=O)C=CC2=C(C=C(C=C2OC)OC)OC)NCC(=O)[O-].[Na+]
Size 5mg
Supplier Page http://www.selleckchem.com/products/ON-01910.html
Additional Information https://file.selleck.cn/downloads/struct/ON-01910-chemical-structure-S1362.gif