Rigosertib (ON-01910)

Rigosertib (ON-01910) is a non-ATP-competitive inhibitor of PLK1 with IC50 of 9 nM in a cell-free assay. It shows 30-fold greater selectivity against Plk2 and no activity to Plk3. Rigosertib inhibits PI3K/Akt pathway and activates oxidative stress signals. Rigosertib induces apoptosis in various cancer cells. Phase 3.

Price Not Available 10mM/1mL Rigosertib (ON-01910) Supplier Page

Trivial name	N/A
Catalog Number	S1362
Molecular Formula	C21H24NNaO8S
CAS#	1225497-78-8
Inchi	InChI=1S/C21H25NO8S.Na/c1-27-15-10-19(29-3)16(20(11-15)30-4)7-8-31(25,26)13-14-5-6-18(28-2)17(9-14)22-12-21(23)24;/h5-11,22H,12-13H2,1-4H3,(H,23,24);/q;+1/p-1/b8-7+;
Inchi Key	VLQLUZFVFXYXQE-USRGLUTNSA-M
SMILES	COC1=C(C=C(C=C1)CS(=O)(=O)C=CC2=C(C=C(C=C2OC)OC)OC)NCC(=O)[O-].[Na+]
Size	10mM/1mL
Supplier Page	http://www.selleckchem.com/products/ON-01910.html
Additional Information	https://file.selleck.cn/downloads/struct/ON-01910-chemical-structure-S1362.gif