Rigosertib (ON-01910)

Rigosertib (ON-01910) is a non-ATP-competitive inhibitor of PLK1 with IC50 of 9 nM in a cell-free assay. It shows 30-fold greater selectivity against Plk2 and no activity to Plk3. Rigosertib inhibits PI3K/Akt pathway and activates oxidative stress signals. Rigosertib induces apoptosis in various cancer cells. Phase 3.

Price Not Available 10mM/1mL Rigosertib (ON-01910) Supplier Page

Trivial name	N/A
Catalog Number	S1362
Molecular Formula	C32H41BrN9O2P
CAS#	1225497-78-8
Inchi	InChI=1S/C32H41BrN9O2P/c1-21-18-26(28(44-3)19-27(21)42-12-8-22(9-13-42)41-16-14-40(2)15-17-41)38-32-36-20-23(33)31(39-32)37-25-7-6-24-29(35-11-10-34-24)30(25)45(4,5)43/h6-7,10-11,18-20,22H,8-9,12-17H2 ,1-5H3,(H2,36,37,38,39)
Inchi Key	ZYSKXRAGBGLELB-UHFFFAOYSA-N
SMILES	CC1=CC(=C(C=C1N2CCC(CC2)N3CCN(CC3)C)OC)NC4=NC=C(C(=N4)NC5=C(C6=NC=CN=C6C=C5)P(=O)(C)C)Br
Size	10mM/1mL
Supplier Page	http://www.selleckchem.com/products/ON-01910.html
Additional Information	https://file.selleck.cn/downloads/struct/ON-01910-chemical-structure-S1362.gif