Rosiglitazone
Rosiglitazone is a potent antihyperglycemic agent and a potent thiazolidinedione insulin sensitizer with IC50 of 12, 4 and 9 nM for rat, 3T3-L1 and human adipocytes, respectively. Rosiglitazone is a pure ligand of PPAR-gamma, and has no PPAR-alpha-binding action. Rosiglitazone modulates TRP channels and induces autophagy. Rosiglitazone prevents ferroptosis.
| Trivial name | BRL 49653 |
| Catalog Number | S2556 |
| Molecular Formula | C21H23N5O3S |
| CAS# | 122320-73-4 |
| Inchi | InChI=1S/C21H23N5O3S/c27-20(17-8-9-17)23-21-22-19-3-1-2-18(26(19)24-21)16-6-4-15(5-7-16)14-25-10-12-30(28,29)13-11-25/h1-7,17H,8-14H2,(H,23,24,27) |
| Inchi Key | RIJLVEAXPNLDTC-UHFFFAOYSA-N |
| SMILES | C1CC1C(=O)NC2=NN3C(=N2)C=CC=C3C4=CC=C(C=C4)CN5CCS(=O)(=O)CC5 |
| Size | 10mM/1mL |
| Supplier Page | http://www.selleckchem.com/products/Rosiglitazone-Avandia.html |
| Additional Information | https://file.selleck.cn/downloads/struct/Rosiglitazone-Avandia-chemical-structure-S2556.gif |