Torin 2

Torin 2 is a potent and selective mTOR inhibitor with IC50 of 0.25 nM in p53−/− MEFs cell line; 800-fold greater selectivity for mTOR than PI3K and improved pharmacokinetic properties. Inhibition of ATM/ATR/DNA-PK with EC50 of 28 nM/35 nM/118 nM,in PC3 cell lines respectively. Torin 2 decreases cell viability and induces autophagy and apoptosis.

Price Not Available 5mg Torin 2 Supplier Page
Trivial name N/A
Catalog Number S2817
Molecular Formula C24H15F3N4O
CAS# 1223001-51-1
Inchi InChI=1S/C24H15F3N4O/c25-24(26,27)17-2-1-3-18(11-17)31-22(32)9-6-16-13-29-20-7-4-14(10-19(20)23(16)31)15-5-8-21(28)30-12-15/h1-13H,(H2,28,30)
Inchi Key GUXXEUUYCAYESJ-UHFFFAOYSA-N
SMILES C1=CC(=CC(=C1)N2C(=O)C=CC3=CN=C4C=CC(=CC4=C32)C5=CN=C(C=C5)N)C(F)(F)F
Size 5mg
Supplier Page http://www.selleckchem.com/products/torin-2.html
Additional Information https://file.selleck.cn/downloads/struct/Torin-2-chemical-structure-s2817.gif