Torin 2
Torin 2 is a potent and selective mTOR inhibitor with IC50 of 0.25 nM in p53−/− MEFs cell line; 800-fold greater selectivity for mTOR than PI3K and improved pharmacokinetic properties. Inhibition of ATM/ATR/DNA-PK with EC50 of 28 nM/35 nM/118 nM,in PC3 cell lines respectively. Torin 2 decreases cell viability and induces autophagy and apoptosis.
| Trivial name | N/A |
| Catalog Number | S2817 |
| Molecular Formula | C24H23F3N6S |
| CAS# | 1223001-51-1 |
| Inchi | InChI=1S/C24H23F3N6S/c1-14-15(2-3-21-19(14)8-17(11-28)31-21)12-33-6-4-16(5-7-33)32-22-20-9-18(10-24(25,26)27)34-23(20)30-13-29-22/h2-3,8-9,13,16,31H,4-7,10,12H2,1H3,(H,29,30,32) |
| Inchi Key | DZACSLYTXLZAAF-UHFFFAOYSA-N |
| SMILES | CC1=C(C=CC2=C1C=C(N2)C#N)CN3CCC(CC3)NC4=C5C=C(SC5=NC=N4)CC(F)(F)F |
| Size | 25mg |
| Supplier Page | http://www.selleckchem.com/products/torin-2.html |
| Additional Information | https://file.selleck.cn/downloads/struct/Torin-2-chemical-structure-s2817.gif |