DDD85646
DDD85646 (IMP-366) is an orally active inhibitor of N-myristoyltransferase(NMT), with an IC50 of 2 nM for Trypanosoma brucei NMT (TbNMT) and 4 nM for human NMT (hNMT). It exhibits a potential for treating human African trypanosomiasis.
| Trivial name | IMP-366 |
| Catalog Number | E5974 |
| Molecular Formula | C38H52N6O7.H2SO4 |
| CAS# | 1215010-55-1 |
| Inchi | InChI=1S/C38H52N6O7.H2O4S/c1-37(2,3)31(41-35(48)50-7)33(46)40-29(22-25-14-10-9-11-15-25)30(45)24-44(43-34(47)32(38(4,5)6)42-36(49)51-8)23-26-17-19-27(20-18-26)28-16-12-13-21-39-28;1-5(2,3)4/h9-21,29-3 2,45H,22-24H2,1-8H3,(H,40,46)(H,41,48)(H,42,49)(H,43,47);(H2,1,2,3,4)/t29-,30-,31+,32+;/m0./s1 |
| Inchi Key | DQSGVVGOPRWTKI-QVFAWCHISA-N |
| SMILES | CC(C)(C)C(C(=O)NC(CC1=CC=CC=C1)C(CN(CC2=CC=C(C=C2)C3=CC=CC=N3)NC(=O)C(C(C)(C)C)NC(=O)OC)O)NC(=O)OC.OS(=O)(=O)O |
| Size | 1g |
| Supplier Page | http://www.selleckchem.com/products/ddd85646.html |
| Additional Information | https://file.selleck.cn/downloads/struct/E5974-DDD85646-chemical-structure.png |