PIM447
PIM447 (LGH447) is a potent, orally available, and selective pan-PIM kinase inhibitor, with Ki values of 6, 18, and 9 pM for PIM1, PIM2, and PIM3, respectively. PIM447 displays dual antimyeloma and bone-protective effects. PIM447 induces apoptosis.
| Trivial name | LGH447 |
| Catalog Number | E8144 |
| Molecular Formula | C26H30O8 |
| CAS# | 1210608-43-7 |
| Inchi | InChI=1S/C26H30O8/c1-22(2)15-9-16(27)24(4)14(25(15)12-31-18(28)10-17(25)33-22)5-7-23(3)19(13-6-8-30-11-13)32-21(29)20-26(23,24)34-20/h6,8,11,14-15,17,19-20H,5,7,9-10,12H2,1-4H3/t14-,15-,17-,19-,20+,23 -,24-,25+,26+/m0/s1 |
| Inchi Key | KBDSLGBFQAGHBE-MSGMIQHVSA-N |
| SMILES | CC1(C2CC(=O)C3(C(C24COC(=O)CC4O1)CCC5(C36C(O6)C(=O)OC5C7=COC=C7)C)C)C |
| Size | 1mg |
| Supplier Page | http://www.selleckchem.com/products/pim447.html |
| Additional Information | https://file.selleck.cn/downloads/struct/e8144-pim447-chemical-structure-tube.png |