Oclacitinib
Oclacitinib(PF-03394197), an inhibitor of JAK is highly potent at inhibiting JAK1 with an IC50 value of 10 nM, respectively. Oclacitinib is highly potent against the JAK1 enzyme, displaying a 1.8-fold selectivity for JAK1 vs. JAK2 and a 9.9-fold selectivity toward JAK1 vs. JAK3.
| Trivial name | PF-03394197 |
| Catalog Number | E4971 |
| Molecular Formula | C11H15N5O5 |
| CAS# | 1208319-26-9 |
| Inchi | InChI=1S/C11H15N5O5/c1-20-9-5-8(14-11(12)15-9)16(3-13-5)10-7(19)6(18)4(2-17)21-10/h3-4,6-7,10,17-19H,2H2,1H3,(H2,12,14,15)/t4-,6-,7+,10-/m1/s1 |
| Inchi Key | IXOXBSCIXZEQEQ-UHTZMRCNSA-N |
| SMILES | COC1=NC(=NC2=C1N=CN2C3C(C(C(O3)CO)O)O)N |
| Size | 1g |
| Supplier Page | http://www.selleckchem.com/products/oclacitinib.html |
| Additional Information | https://file.selleck.cn/downloads/struct/E4971-Oclacitinib-chemical-structure.png |